| Reaction Details |
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 | Report a problem with these data |
| Target | Bombesin receptor subtype-3 |
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| Ligand | BDBM50336889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_718503 (CHEMBL1680298) |
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| Ki | 0.60±n/a nM |
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| Citation |  Sebhat, IK; Franklin, C; Lo, MM; Chen, D; Jewell, JP; Miller, R; Pang, J; Palyha, O; Kan, Y; Kelly, TM; Guan, XM; Marsh, DJ; Kosinski, JA; Metzger, JM; Lyons, K; Dragovic, J; Guzzo, PR; Henderson, AJ; Reitman, ML; Nargund, RP; Wyvratt, MJ Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity ACS Med Chem Lett2:43-47 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bombesin receptor subtype-3 |
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| Name: | Bombesin receptor subtype-3 |
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| Synonyms: | BRS3_RAT | Bombesin | Brs3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44213.49 |
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| Organism: | RAT |
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| Description: | Bombesin 0 RAT::Q8K418 |
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| Residue: | 399 |
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| Sequence: | MSQRQPQSPNQTLISITNDTETSSSAVSNDTTPKGWTGDNSPGIEALCAIYITYAVIISV
GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGC
KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFAL
PEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLI
ARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYES
YAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLCCFKAEQPEPPLGDT
PLNNLTVMGRVPATGSAHVSEISVTLFSGSTAKKGEDKV
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| BDBM50336889 |
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| n/a |
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| Name | BDBM50336889 |
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| Synonyms: | (2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)propan-2-ol | CHEMBL1672354 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F6N4O |
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| Mol. Mass. | 444.3735 |
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| SMILES | O[C@@](Cc1ncc(CC2(CC2)C(F)(F)F)[nH]1)(c1ccc(cc1)-n1cccn1)C(F)(F)F |r| |
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| Structure | 
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