| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50336957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_718609 (CHEMBL1680635) |
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| EC50 | 325±n/a nM |
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| Citation |  Lanman, BA; Cee, VJ; Cheruku, SR; Frohn, M; Golden, J; Lin, J; Lobera, M; Marantz, Y; Muller, KM; Neira, SC; Pickrell, AJ; Rivenzon-Segal, D; Schutz, N; Sharadendu, A; Yu, X; Zhang, Z; Buys, J; Fiorino, M; Gore, A; Horner, M; Itano, A; McElvain, M; Middleton, S; Schrag, M; Vargas, HM; Xu, H; Xu, Y; Zhang, X; Siu, J Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) ACS Med Chem Lett2:102-106 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50336957 |
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| n/a |
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| Name | BDBM50336957 |
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| Synonyms: | 1-(4-(5-Benzylbenzo[d]oxazol-2-yl)-3-fluorobenzyl)azetidine-3-carboxylic acid | CHEMBL1672550 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21FN2O3 |
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| Mol. Mass. | 416.4442 |
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| SMILES | OC(=O)C1CN(Cc2ccc(-c3nc4cc(Cc5ccccc5)ccc4o3)c(F)c2)C1 |
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| Structure | 
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