| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 3 |
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| Ligand | BDBM50337038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_718713 (CHEMBL1680932) |
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| EC50 | 300±n/a nM |
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| Citation |  Qin, J; Rao, A; Chen, X; Zhu, X; Liu, Z; Huang, X; Degrado, S; Huang, Y; Xiao, D; Aslanian, R; Cheewatrakoolpong, B; Zhang, H; Greenfeder, S; Farley, C; Cook, J; Kurowski, S; Li, Q; Heek, Mv; Chintala, M; Wang, G; Hsieh, Y; Li, F Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ACS Med Chem Lett2:171-176 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 3 |
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| Name: | Hydroxycarboxylic acid receptor 3 |
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| Synonyms: | G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44498.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | GPR109B 0 HUMAN::P49019 |
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| Residue: | 387 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
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| BDBM50337038 |
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| n/a |
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| Name | BDBM50337038 |
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| Synonyms: | 5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione | CHEMBL1671877 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14F2N2O3 |
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| Mol. Mass. | 296.2694 |
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| SMILES | FC(F)c1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1 |
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| Structure | 
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