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TargetHydroxycarboxylic acid receptor 3
LigandBDBM23515
Substrate/Competitorn/a
Meas. Tech.ChEMBL_718713 (CHEMBL1680932)
EC50>10000±n/a nM
Citation Qin, JRao, AChen, XZhu, XLiu, ZHuang, XDegrado, SHuang, YXiao, DAslanian, RCheewatrakoolpong, BZhang, HGreenfeder, SFarley, CCook, JKurowski, SLi, QHeek, MvChintala, MWang, GHsieh, YLi, F Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ACS Med Chem Lett2:171-176 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 3
Name:Hydroxycarboxylic acid receptor 3
Synonyms:G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:Enzyme Catalytic Domain
Mol. Mass.:44498.06
Organism:Homo sapiens (Human)
Description:GPR109B 0 HUMAN::P49019
Residue:387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
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  Blast E-value cutoff:
BDBM23515
n/a
NameBDBM23515
Synonyms:CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-niacin | pyridine-3-carboxylic acid | wampocap
TypeSmall organic molecule
Emp. Form.C6H5NO2
Mol. Mass.123.1094
SMILESOC(=O)c1cccnc1
Structure
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