| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM50337418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_728369 (CHEMBL1685145) |
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| Ki | 1.9±n/a nM |
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| Citation |  Juhl, K; Hansen, T; Kehler, J; Khanzhin, NA; Nørgaard, MB; Ruhland, T; Larsen, DB; Jensen, KG; Steiniger-Brach, B; Nielsen, SM; Simonsen, KB Identification of a new series of non-peptidic NK3 receptor antagonists. Bioorg Med Chem Lett21:1498-501 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52221.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29371 |
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| Residue: | 465 |
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| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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| BDBM50337418 |
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| n/a |
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| Name | BDBM50337418 |
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| Synonyms: | (1S,2R)-1-(3,4-dichlorophenyl)-2-((3-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)azetidin-1-yl)methyl)-N-(4-fluorobenzyl)-N-methylcyclopropanecarboxamide | CHEMBL1682683 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36Cl2FN5O3S |
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| Mol. Mass. | 612.587 |
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| SMILES | CN(C)S(=O)(=O)N1CCN(CC1)C1CN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccc(F)cc2)c2ccc(Cl)c(Cl)c2)C1 |r| |
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| Structure | 
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