Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetC-C chemokine receptor type 2
LigandBDBM50337634
Substrate/Competitorn/a
Meas. Tech.ChEMBL_728647 (CHEMBL1685777)
IC50 3.4±n/a nM
Citation Zheng, CCao, GXia, MFeng, HGlenn, JAnand, RZhang, KHuang, TWang, AKong, LLi, MGalya, LHughes, RODevraj, RMorton, PARogier, DJCovington, MBaribaud, FShin, NScherle, PDiamond, SYeleswaram, SVaddi, KNewton, RHollis, GFriedman, SMetcalf, BXue, CB Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist. Bioorg Med Chem Lett21:1442-6 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 2
Name:C-C chemokine receptor type 2
Synonyms:C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:Enzyme
Mol. Mass.:41932.32
Organism:Homo sapiens (Human)
Description:P41597
Residue:374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50337634
n/a
NameBDBM50337634
Synonyms:((1S,3R)-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)-1-(2,2,2-trifluoroethyl)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone | CHEMBL1683190
TypeSmall organic molecule
Emp. Form.C24H32F6N4O3
Mol. Mass.538.5263
SMILESCO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](CC(F)(F)F)(C1)C(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: