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TargetC-C chemokine receptor type 2
LigandBDBM50337619
Substrate/Competitorn/a
Meas. Tech.ChEMBL_728653 (CHEMBL1685783)
IC50 2.9±n/a nM
Citation Zheng, CCao, GXia, MFeng, HGlenn, JAnand, RZhang, KHuang, TWang, AKong, LLi, MGalya, LHughes, RODevraj, RMorton, PARogier, DJCovington, MBaribaud, FShin, NScherle, PDiamond, SYeleswaram, SVaddi, KNewton, RHollis, GFriedman, SMetcalf, BXue, CB Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist. Bioorg Med Chem Lett21:1442-6 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 2
Name:C-C chemokine receptor type 2
Synonyms:C-C CKR-2 | CC-CKR-2 | CCR-2 | CCR2_RAT | CD_antigen=CD192 | Ccr2 | Cmkbr2
Type:PROTEIN
Mol. Mass.:42771.06
Organism:Rattus norvegicus
Description:ChEMBL_819962
Residue:373
Sequence:
MEDSNMLPQFIHGILSTSHSLFPRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPP
LYSLVFIFGFVGNMLVIIILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANEWV
FGNIMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVV
AVFASLPGIIFTKSEQEDDQHTCGPYFPTIWKNFQTIMRNILSLILPLLVMVICYSGILH
TLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQEFLGMSNCVVDMHLDQAM
QVTETLGMTHCCVNPIIYAFVGEKFRRYLSIFFRKHIAKNLCKQCPVFYRETADRVSSTF
TPSTGEQEVSVGL
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BDBM50337619
n/a
NameBDBM50337619
Synonyms:((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone | ((3S,4S)-N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-3-methoxytetrahydro-2H-pyran-4-amine | CHEMBL1683074
TypeSmall organic molecule
Emp. Form.C25H37F3N4O3
Mol. Mass.498.5815
SMILESCO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F |r|
Structure
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