| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin E synthase |
|---|
| Ligand | BDBM50227631 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_728758 (CHEMBL1686171) |
|---|
| IC50 | 420±n/a nM |
|---|
| Citation |  Chiasson, JF; Boulet, L; Brideau, C; Chau, A; Claveau, D; Côté, B; Ethier, D; Giroux, A; Guay, J; Guiral, S; Mancini, J; Massé, F; Méthot, N; Riendeau, D; Roy, P; Rubin, J; Xu, D; Yu, H; Ducharme, Y; Friesen, RW Trisubstituted ureas as potent and selective mPGES-1 inhibitors. Bioorg Med Chem Lett21:1488-92 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin E synthase |
|---|
| Name: | Prostaglandin E synthase |
|---|
| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 17112.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 152 |
|---|
| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
|
|
|
|---|
| BDBM50227631 |
|---|
| n/a |
|---|
| Name | BDBM50227631 |
|---|
| Synonyms: | 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL412099 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H11ClN4 |
|---|
| Mol. Mass. | 378.813 |
|---|
| SMILES | Clc1ccc2c3[nH]c(nc3c3ccccc3c2c1)-c1c(cccc1C#N)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
