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TargetProstaglandin E synthase
LigandBDBM50337669
Substrate/Competitorn/a
Meas. Tech.ChEMBL_728757 (CHEMBL1686170)
IC50 260±n/a nM
Citation Chiasson, JFBoulet, LBrideau, CChau, AClaveau, DCôté, BEthier, DGiroux, AGuay, JGuiral, SMancini, JMassé, FMéthot, NRiendeau, DRoy, PRubin, JXu, DYu, HDucharme, YFriesen, RW Trisubstituted ureas as potent and selective mPGES-1 inhibitors. Bioorg Med Chem Lett21:1488-92 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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BDBM50337669
n/a
NameBDBM50337669
Synonyms:1-benzyl-2-cyano-3-isopropyl-1-(3-(phenylethynyl)benzyl)guanidine | CHEMBL1683227
TypeSmall organic molecule
Emp. Form.C27H26N4
Mol. Mass.406.5221
SMILESCC(C)NC(=NC#N)N(Cc1ccccc1)Cc1cccc(c1)C#Cc1ccccc1 |w:5.5|
Structure
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