Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase ITK/TSK |
---|
Ligand | BDBM50338046 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_727521 (CHEMBL1685631) |
---|
IC50 | 98±n/a nM |
---|
Citation | Herdemann, M; Weber, A; Jonveaux, J; Schwoebel, F; Stoeck, M; Heit, I Optimisation of ITK inhibitors through successive iterative design cycles. Bioorg Med Chem Lett21:1852-6 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase ITK/TSK |
---|
Name: | Tyrosine-protein kinase ITK/TSK |
Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
Type: | Protein |
Mol. Mass.: | 71839.20 |
Organism: | Homo sapiens (Human) |
Description: | Q08881 |
Residue: | 620 |
Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
|
|
|
BDBM50338046 |
---|
n/a |
---|
Name | BDBM50338046 |
Synonyms: | 2-methoxy-N-(3-(6-methoxy-1H-indol-2-yl)-1H-indazol-5-yl)acetamide | CHEMBL1684509 |
Type | Small organic molecule |
Emp. Form. | C19H18N4O3 |
Mol. Mass. | 350.3712 |
SMILES | COCC(=O)Nc1ccc2[nH]nc(-c3cc4ccc(OC)cc4[nH]3)c2c1 |
Structure |
|