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TargetTyrosine-protein kinase ITK/TSK
LigandBDBM50338074
Substrate/Competitorn/a
Meas. Tech.ChEMBL_727521 (CHEMBL1685631)
IC50 60±n/a nM
Citation Herdemann, MWeber, AJonveaux, JSchwoebel, FStoeck, MHeit, I Optimisation of ITK inhibitors through successive iterative design cycles. Bioorg Med Chem Lett21:1852-6 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ITK/TSK
Name:Tyrosine-protein kinase ITK/TSK
Synonyms:EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:Protein
Mol. Mass.:71839.20
Organism:Homo sapiens (Human)
Description:Q08881
Residue:620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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  Blast E-value cutoff:
BDBM50338074
n/a
NameBDBM50338074
Synonyms:CHEMBL1684676 | N-benzyl-2-(1H-indazol-3-yl)-N-methyl-1H-indole-6-carboxamide
TypeSmall organic molecule
Emp. Form.C24H20N4O
Mol. Mass.380.4418
SMILESCN(Cc1ccccc1)C(=O)c1ccc2cc([nH]c2c1)-c1n[nH]c2ccccc12
Structure
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