| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
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| Ligand | BDBM50338112 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727521 (CHEMBL1685631) |
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| IC50 | 30±n/a nM |
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| Citation |  Herdemann, M; Weber, A; Jonveaux, J; Schwoebel, F; Stoeck, M; Heit, I Optimisation of ITK inhibitors through successive iterative design cycles. Bioorg Med Chem Lett21:1852-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ITK/TSK |
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| Name: | Tyrosine-protein kinase ITK/TSK |
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| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
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| Type: | Protein |
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| Mol. Mass.: | 71839.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08881 |
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| Residue: | 620 |
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| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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| BDBM50338112 |
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| n/a |
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| Name | BDBM50338112 |
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| Synonyms: | CHEMBL1684655 | N-(1-benzylpyrrolidin-3-yl)-3-(6-methyl-1H-indol-2-yl)-1H-indazol-5-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N5 |
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| Mol. Mass. | 421.5368 |
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| SMILES | Cc1ccc2cc([nH]c2c1)-c1n[nH]c2ccc(NC3CCN(Cc4ccccc4)C3)cc12 |
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| Structure | 
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