| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 9 |
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| Ligand | BDBM50338273 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727961 (CHEMBL1686759) |
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| IC50 | 28400±n/a nM |
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| Citation |  Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Tóth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorg Med Chem Lett21:1838-43 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 9 |
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| Name: | Mitogen-activated protein kinase 9 |
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| Synonyms: | JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48131.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 424 |
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| Sequence: | MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
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| BDBM50338273 |
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| n/a |
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| Name | BDBM50338273 |
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| Synonyms: | CHEMBL1681997 | ethyl 4-ethynyl-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17NO4S |
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| Mol. Mass. | 343.397 |
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| SMILES | CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#C |
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| Structure | 
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