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TargetMitogen-activated protein kinase 9
LigandBDBM50338267
Substrate/Competitorn/a
Meas. Tech.ChEMBL_727961 (CHEMBL1686759)
IC50 41±n/a nM
Citation Bowers, STruong, APNeitz, RJNeitzel, MProbst, GDHom, RKPeterson, BGalemmo, RAKonradi, AWSham, HLTóth, GPan, HYao, NArtis, DRBrigham, EFQuinn, KPSauer, JMPowell, KRuslim, LRen, ZBard, FYednock, TAGriswold-Prenner, I Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorg Med Chem Lett21:1838-43 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 9
Name:Mitogen-activated protein kinase 9
Synonyms:JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:Enzyme
Mol. Mass.:48131.49
Organism:Homo sapiens (Human)
Description:JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
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  Blast E-value cutoff:
BDBM50338267
n/a
NameBDBM50338267
Synonyms:CHEMBL1682021 | N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | US9796706, Compound 39
TypeSmall organic molecule
Emp. Form.C18H12N6OS
Mol. Mass.360.392
SMILESO=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Structure
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