Reaction Details |
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Target | Mitogen-activated protein kinase 10 |
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Ligand | BDBM50338286 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_727960 (CHEMBL1686758) |
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IC50 | 594±n/a nM |
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Citation | Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Tóth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorg Med Chem Lett21:1838-43 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 10 |
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Name: | Mitogen-activated protein kinase 10 |
Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
Type: | Enzyme |
Mol. Mass.: | 52586.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 464 |
Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
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BDBM50338286 |
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n/a |
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Name | BDBM50338286 |
Synonyms: | CHEMBL1682009 | N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinoxalin-5-yl)acetamide |
Type | Small organic molecule |
Emp. Form. | C18H16N6OS |
Mol. Mass. | 364.424 |
SMILES | Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12 |
Structure |
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