| Reaction Details |
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 | Report a problem with these data |
| Target | Methylated-DNA--protein-cysteine methyltransferase |
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| Ligand | BDBM50106517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_728308 (CHEMBL1687568) |
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| IC50 | 3±n/a nM |
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| Citation |  Lopez, S; Margison, GP; McElhinney, RS; Cordeiro, A; McMurry, TB; Rozas, I Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators. Bioorg Med Chem19:1658-65 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methylated-DNA--protein-cysteine methyltransferase |
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| Name: | Methylated-DNA--protein-cysteine methyltransferase |
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| Synonyms: | 6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21651.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_144711 |
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| Residue: | 207 |
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| Sequence: | MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
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| BDBM50106517 |
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| n/a |
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| Name | BDBM50106517 |
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| Synonyms: | 6-(4-Bromo-thiophen-2-ylmethoxy)-9H-purin-2-ylamine | CHEMBL339133 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8BrN5OS |
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| Mol. Mass. | 326.172 |
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| SMILES | Nc1nc(OCc2cc(Br)cs2)c2[nH]cnc2n1 |
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| Structure | 
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