Ki Summary

Reaction Details

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Target

NADP-dependent malic enzyme

Ligand

BDBM50338502

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_728315 (CHEMBL1687575)

57000±n/a nM

Citation

Hou, S; Liu, W; Ji, D; Zhao, ZK Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme. Bioorg Med Chem Lett21:1667-9 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

NADP-dependent malic enzyme

Name:

NADP-dependent malic enzyme

Synonyms:

MAO2_ECOLI | NADP-ME | maeB | ypfF

Type:

PROTEIN

Mol. Mass.:

82404.36

Organism:

Escherichia coli (strain K12)

Description:

ChEMBL_728315

Residue:

759

Sequence:

MDDQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLKAYKY
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFI
EVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISTAAILNGLRV
VEKNISDVRMVVSGAGAAAIACMNLLVALGLQKHNIVVCDSKGVIYQGREPNMAETKAAY
AVVDDGKRTLDDVIEGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKE
VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQS
EVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMESGVATRPIADFDVYIDKL
TEFVYKTNLFMKPIFSQARKAPKRVVLPEGEEARVLHATQELVTLGLAKPILIGRPNVIE
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWTEYFQIMKRRGVTQEQAQRALISNPTVIG
AIMVQRGEADAMICGTVGDYHEHFSVVKNVFGYRDGVHTAGAMNALLLPSGNTFIADTYV
NDEPDAEELAEITLMAAETVRRFGIEPRVALLSHSNFGSSDCPSSSKMRQALELVRERAP
ELMIDGEMHGDAALVEAIRNDRMPDSSLKGSANILVMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVAKPVHVLTPIASVRRIVNMVALAVVEAQTQPL

BDBM50338502

n/a

Name

BDBM50338502

Synonyms:

5-O-phosphate-1-N-(4'-(4''-methoxyhenyl))-[1',2',3']-triazol-beta-D-ribofuranoside | CHEMBL1683319

Type

Small organic molecule

Emp. Form.

C14H18N3O8P

Mol. Mass.

387.2818

SMILES

COc1ccc(cc1)-c1cn(nn1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r|

Structure