| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
|---|
| Ligand | BDBM50338523 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_728487 (CHEMBL1685364) |
|---|
| IC50 | 11±n/a nM |
|---|
| Citation |  Atkinson, KA; Beretta, EE; Brown, JA; Castrodad, M; Chen, Y; Cosgrove, JM; Du, P; Litchfield, J; Makowski, M; Martin, K; McLellan, TJ; Neagu, C; Perry, DA; Piotrowski, DW; Steppan, CM; Trilles, R N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett21:1621-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA desaturase 1 |
|---|
| Name: | Acyl-CoA desaturase 1 |
|---|
| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41485.97 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07308 |
|---|
| Residue: | 358 |
|---|
| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
|
|
|
|---|
| BDBM50338523 |
|---|
| n/a |
|---|
| Name | BDBM50338523 |
|---|
| Synonyms: | CHEMBL1683578 | N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(trifluoromethyl)benzyl)-1H-imidazole-4-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14F3N5O |
|---|
| Mol. Mass. | 349.3105 |
|---|
| SMILES | Cn1ccc(NC(=O)c2cn(Cc3cccc(c3)C(F)(F)F)cn2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
