| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 1 |
|---|
| Ligand | BDBM19264 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_728668 (CHEMBL1685945) |
|---|
| Ki | 33±n/a nM |
|---|
| Citation |  Felczak, K; Chen, L; Wilson, D; Williams, J; Vince, R; Petrelli, R; Jayaram, HN; Kusumanchi, P; Kumar, M; Pankiewicz, KW Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain. Bioorg Med Chem19:1594-605 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inosine-5'-monophosphate dehydrogenase 1 |
|---|
| Name: | Inosine-5'-monophosphate dehydrogenase 1 |
|---|
| Synonyms: | IMDH1_HUMAN | IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH-I | IMPDH1 | Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55407.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant IMPDH1 expressed in E. coli. |
|---|
| Residue: | 514 |
|---|
| Sequence: | MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
|
|
|
|---|
| BDBM19264 |
|---|
| n/a |
|---|
| Name | BDBM19264 |
|---|
| Synonyms: | (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid | (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid | CHEMBL866 | MPA (1) | Mycophenolic Acid (MPA) | Myfortic |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H20O6 |
|---|
| Mol. Mass. | 320.3371 |
|---|
| SMILES | COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
