| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50338684 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_726871 (CHEMBL1686577) |
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| Ki | 15±n/a nM |
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| Citation |  Young, RJ; Adams, C; Blows, M; Brown, D; Burns-Kurtis, CL; Chan, C; Chaudry, L; Convery, MA; Davies, DE; Exall, AM; Foster, G; Harling, JD; Hortense, E; Irvine, S; Irving, WR; Jackson, S; Kleanthous, S; Pateman, AJ; Patikis, AN; Roethka, TJ; Senger, S; Stelman, GJ; Toomey, JR; West, RI; Whittaker, C; Zhou, P; Watson, NS Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs. Bioorg Med Chem Lett21:1582-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50338684 |
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| n/a |
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| Name | BDBM50338684 |
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| Synonyms: | (R/S)-(E)-2-(5-chlorothiophen-2-yl)-N-((3S)-1-(2-fluoro-4-(1-methylpyrrolidin-2-yl)phenyl)-2-oxopyrrolidin-3-yl)ethenesulfonamide | CHEMBL1684186 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23ClFN3O3S2 |
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| Mol. Mass. | 484.007 |
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| SMILES | CN1CCCC1c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 |r| |
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| Structure | 
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