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TargetCoagulation factor X
LigandBDBM50338686
Substrate/Competitorn/a
Meas. Tech.ChEMBL_726871
Ki 0.3±n/a nM
Citation Young RJAdams CBlows MBrown DBurns-Kurtis CLChan CChaudry LConvery MADavies DEExall AMFoster GHarling JDHortense EIrvine SIrving WRJackson SKleanthous SPateman AJPatikis ANRoethka TJSenger SStelman GJToomey JRWest RIWhittaker CZhou PWatson NS Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs. Bioorg Med Chem Lett 21:1582-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50338686
n/a
NameBDBM50338686
Synonyms:(R/S)-3-chloro-N-((3S)-1-(1-(methylamino)-2,3-dihydro-1H-inden-5-yl)-2-oxopyrrolidin-3-yl)-1H-indole-6-sulfonamide | CHEMBL1684184
TypeSmall organic molecule
Emp. Form.C22H23ClN4O3S
Mol. Mass.458.961
SMILESCNC1CCc2cc(ccc12)N1CC[C@H](NS(=O)(=O)c2ccc3c(Cl)c[nH]c3c2)C1=O |r|
Structure
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