| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell receptor CD22 |
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| Ligand | BDBM50274303 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727026 (CHEMBL1686886) |
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| IC50 | 530±n/a nM |
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| Citation |  Abdu-Allah, HH; Watanabe, K; Completo, GC; Sadagopan, M; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Paulson, JC; Tsubata, T; Ando, H; Ishida, H; Kiso, M CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold. Bioorg Med Chem19:1966-71 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell receptor CD22 |
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| Name: | B-cell receptor CD22 |
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| Synonyms: | CD22 | CD22_HUMAN | SIGLEC2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95348.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_727026 |
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| Residue: | 847 |
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| Sequence: | MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFH
NPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLR
MESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEG
VPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKH
TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT
KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL
PTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK
KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNT
TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ
FFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM
SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQ
GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQG
LQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAES
SEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV
DYVILKH
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| BDBM50274303 |
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| n/a |
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| Name | BDBM50274303 |
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| Synonyms: | CHEMBL502862 | p-Methoxyphenyl (3,5,9-trideoxy-5-glycolamido-9-(4-hydroxy-4-biphenyl)-methylamino-D-glycero-alpha-D-galacto-2-nonulopyranosylonicacid)-(2->6)-beta-D-galactopyranoside |
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| Type | Small organic molecule |
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| Emp. Form. | C37H46N2O16 |
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| Mol. Mass. | 774.7649 |
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| SMILES | COc1ccc(O[C@@H]2O[C@H](CO[C@@]3(C[C@H](O)[C@@H](NC(=O)CO)[C@@H](O3)[C@H](O)[C@H](O)CNCc3ccc(cc3)-c3ccc(O)cc3)C(O)=O)[C@H](O)[C@H](O)[C@H]2O)cc1 |r| |
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| Structure | 
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