| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
|---|
| Ligand | BDBM50324896 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_730141 (CHEMBL1696021) |
|---|
| EC50 | 5.3±n/a nM |
|---|
| Citation |  Ohsawa, F; Morishita, K; Yamada, S; Makishima, M; Kakuta, H Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers. ACS Med Chem Lett1:521-525 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor RXR-alpha |
|---|
| Name: | Retinoic acid receptor RXR-alpha |
|---|
| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50820.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1456363 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
|
|
|
|---|
| BDBM50324896 |
|---|
| n/a |
|---|
| Name | BDBM50324896 |
|---|
| Synonyms: | 6-[N-Ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)amino]nicotinic acid | CHEMBL1221641 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H28N2O2 |
|---|
| Mol. Mass. | 352.4699 |
|---|
| SMILES | CCN(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cn1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
