Reaction Details | |||
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Target | Peptidyl-prolyl cis-trans isomerase A | ||
Ligand | BDBM50339126 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_730318 (CHEMBL1696682) | ||
Ki | 2.11±n/a nM | ||
Citation | Ptak, RG; Gallay, PA; Jochmans, D; Halestrap, AP; Ruegg, UT; Pallansch, LA; Bobardt, MD; de Béthune, MP; Neyts, J; De Clercq, E; Dumont, JM; Scalfaro, P; Besseghir, K; Wenger, RM; Rosenwirth, B Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. Antimicrob Agents Chemother52:1302-17 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Peptidyl-prolyl cis-trans isomerase A | |||
Name: | Peptidyl-prolyl cis-trans isomerase A | ||
Synonyms: | CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A | ||
Type: | Protein | ||
Mol. Mass.: | 18015.32 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P62937 | ||
Residue: | 165 | ||
Sequence: |
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BDBM50339126 | |||
n/a | |||
Name | BDBM50339126 | ||
Synonyms: | (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-24-sec-butyl-30-ethyl-33-((1R,2R)-1-hydroxy-2-methylhex-4-enyl)-6,9,18-triisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone | CHEMBL1688529 | ||
Type | Small organic molecule | ||
Emp. Form. | C62H111N11O12 | ||
Mol. Mass. | 1202.6112 | ||
SMILES | CC[C@H](C)[C@@H]1N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC1=O)C(C)C |r| | ||
Structure |