Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50339240 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_736201 (CHEMBL1693237) |
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Ki | 0.47±n/a nM |
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Citation | Mallareddy, JR; Borics, A; Keresztes, A; Kövér, KE; Tourwé, D; Tóth, G Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications. J Med Chem54:1462-72 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50339240 |
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n/a |
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Name | BDBM50339240 |
Synonyms: | (1S,2R)-N-((S)-1-((2S,3S)-1-amino-1-oxo-3-phenylbutan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-(2-amino-3-(4-hydroxy-3,5-dimethylphenyl)propanamido)cyclohexanecarboxamide | CHEMBL1689548 |
Type | Small organic molecule |
Emp. Form. | C37H47N5O5 |
Mol. Mass. | 641.7996 |
SMILES | C[C@H]([C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCC[C@H]1NC(=O)C(N)Cc1cc(C)c(O)c(C)c1)C(N)=O)c1ccccc1 |r| |
Structure |
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