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TargetFalcipain-2
LigandBDBM50339254
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736241
IC50 49900±n/a nM
Citation Praveen Kumar SGut JGuedes RCRosenthal PJSantos MMMoreira R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem 46:927-33 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Falcipain-2
Name:Falcipain-2
Synonyms:n/a
Type:Enzyme
Mol. Mass.:55912.57
Organism:Plasmodium falciparum
Description:n/a
Residue:484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50339254
n/a
NameBDBM50339254
Synonyms:(Z/E)-(S)-N-isopentyl-2-((2-oxoindolin-3-ylidene)methylamino)-4-phenylbutanamide | CHEMBL1689609
TypeSmall organic molecule
Emp. Form.C24H29N3O2
Mol. Mass.391.506
SMILESCC(C)CCNC(=O)[C@H](CCc1ccccc1)N=CC1C(=O)Nc2ccccc12 |r,w:18.19|
Structure
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