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TargetCysteine proteinase falcipain 3
LigandBDBM50339254
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736242 (CHEMBL1693386)
IC50>50000±n/a nM
Citation Praveen Kumar, SGut, JGuedes, RCRosenthal, PJSantos, MMMoreira, R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem46:927-33 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cysteine proteinase falcipain 3
Name:Cysteine proteinase falcipain 3
Synonyms:Cysteine protease falcipain-3
Type:Protein
Mol. Mass.:56666.98
Organism:Plasmodium falciparum
Description:Q9NAW4
Residue:492
Sequence:
MEYHMEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNEN
NKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMN
MNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNK
KYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGP
FKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVG
SVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSN
LPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECG
AAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTC
SIGTEAYVPLLE
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  Blast E-value cutoff:
BDBM50339254
n/a
NameBDBM50339254
Synonyms:(Z/E)-(S)-N-isopentyl-2-((2-oxoindolin-3-ylidene)methylamino)-4-phenylbutanamide | CHEMBL1689609
TypeSmall organic molecule
Emp. Form.C24H29N3O2
Mol. Mass.391.506
SMILESCC(C)CCNC(=O)[C@H](CCc1ccccc1)N=CC1C(=O)Nc2ccccc12 |r,w:18.19|
Structure
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