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TargetPotassium voltage-gated channel subfamily KQT member 2/3
LigandBDBM50339282
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736251 (CHEMBL1693395)
EC50 150±n/a nM
Citation Qi, JZhang, FMi, YFu, YXu, WZhang, DWu, YDu, XJia, QWang, KZhang, H Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur J Med Chem46:934-43 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily KQT member 2/3
Name:Potassium voltage-gated channel subfamily KQT member 2/3
Synonyms:Voltage-gated potassium channel subunit Kv7.2/Kv7.3 | Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3)
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 91707
Components:This complex has 3 components.
Component 1
Name:Potassium voltage-gated channel subfamily KQT member 2
Synonyms:KCNQ (Kv7) potassium channel | KCNQ2 | KCNQ2_HUMAN | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2
Type:PROTEIN
Mol. Mass.:95883.20
Organism:Homo sapiens (Human)
Description:ChEMBL_1457496
Residue:872
Sequence:
MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP
CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV
PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI
RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT
DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG
AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP
QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN
LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD
TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
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Component 2
Name:Potassium voltage-gated channel subfamily KQT member 3
Synonyms:KCNQ (Kv7) potassium channel | KCNQ3 | KCNQ3_HUMAN | Voltage-gated potassium channel subunit Kv7.3
Type:PROTEIN
Mol. Mass.:96759.41
Organism:Homo sapiens (Human)
Description:ChEMBL_938652
Residue:872
Sequence:
MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG
ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG
WALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC
CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM
DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF
ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ
EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS
SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA
YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
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BDBM50339282
n/a
NameBDBM50339282
Synonyms:5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | CHEMBL1689655
TypeSmall organic molecule
Emp. Form.C22H10Cl2F4N4O
Mol. Mass.493.241
SMILESFc1cc(c(Cl)nc1Cl)-c1cc(=O)n2[nH]c(c(-c3cccc4ccccc34)c2n1)C(F)(F)F |(3.56,-4.78,;2.23,-5.55,;.89,-4.79,;-.44,-5.56,;-.44,-7.1,;-1.78,-7.87,;.89,-7.88,;2.23,-7.11,;3.57,-7.88,;-1.77,-4.79,;-3.1,-5.55,;-4.43,-4.79,;-5.77,-5.56,;-4.43,-3.24,;-5.57,-2.22,;-4.96,-.81,;-3.43,-.96,;-2.6,.34,;-3.32,1.7,;-2.5,3,;-.95,2.93,;-.23,1.57,;1.3,1.51,;2.01,.15,;1.19,-1.16,;-.35,-1.09,;-1.06,.27,;-3.1,-2.46,;-1.77,-3.24,;-5.74,.52,;-4.97,1.86,;-7.28,.51,;-6.52,1.86,)|
Structure
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