Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily KQT member 2/3 | ||
Ligand | BDBM50339282 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_736251 (CHEMBL1693395) | ||
EC50 | 150±n/a nM | ||
Citation | Qi, J; Zhang, F; Mi, Y; Fu, Y; Xu, W; Zhang, D; Wu, Y; Du, X; Jia, Q; Wang, K; Zhang, H Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur J Med Chem46:934-43 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily KQT member 2/3 | |||
Name: | Potassium voltage-gated channel subfamily KQT member 2/3 | ||
Synonyms: | Voltage-gated potassium channel subunit Kv7.2/Kv7.3 | Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of EBI is 91707 | ||
Components: | This complex has 3 components. | ||
Component 1 | |||
Name: | Potassium voltage-gated channel subfamily KQT member 2 | ||
Synonyms: | KCNQ (Kv7) potassium channel | KCNQ2 | KCNQ2_HUMAN | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 95883.20 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1457496 | ||
Residue: | 872 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Potassium voltage-gated channel subfamily KQT member 3 | ||
Synonyms: | KCNQ (Kv7) potassium channel | KCNQ3 | KCNQ3_HUMAN | Voltage-gated potassium channel subunit Kv7.3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 96759.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_938652 | ||
Residue: | 872 | ||
Sequence: |
| ||
BDBM50339282 | |||
n/a | |||
Name | BDBM50339282 | ||
Synonyms: | 5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | CHEMBL1689655 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H10Cl2F4N4O | ||
Mol. Mass. | 493.241 | ||
SMILES | Fc1cc(c(Cl)nc1Cl)-c1cc(=O)n2[nH]c(c(-c3cccc4ccccc34)c2n1)C(F)(F)F |(3.56,-4.78,;2.23,-5.55,;.89,-4.79,;-.44,-5.56,;-.44,-7.1,;-1.78,-7.87,;.89,-7.88,;2.23,-7.11,;3.57,-7.88,;-1.77,-4.79,;-3.1,-5.55,;-4.43,-4.79,;-5.77,-5.56,;-4.43,-3.24,;-5.57,-2.22,;-4.96,-.81,;-3.43,-.96,;-2.6,.34,;-3.32,1.7,;-2.5,3,;-.95,2.93,;-.23,1.57,;1.3,1.51,;2.01,.15,;1.19,-1.16,;-.35,-1.09,;-1.06,.27,;-3.1,-2.46,;-1.77,-3.24,;-5.74,.52,;-4.97,1.86,;-7.28,.51,;-6.52,1.86,)| | ||
Structure |