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TargetMelanocortin receptor 1
LigandBDBM50339348
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736466
EC50 0.350000±n/a nM
Citation Singh AWilczynski AHolder JRWitek RMDirain MLXiang ZEdison ASHaskell-Luevano C Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR. J Med Chem 54:1379-90 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 1
Name:Melanocortin receptor 1
Synonyms:MC1-R | MSH-R | Melanocyte-stimulating hormone receptor
Type:PROTEIN
Mol. Mass.:35238.60
Organism:Mus musculus
Description:ChEMBL_1498846
Residue:315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW
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  Blast E-value cutoff:
BDBM50339348
n/a
NameBDBM50339348
Synonyms:(4R,7S,10S,13S,16S,19S,22R,25S,28R)-25-((1H-imidazol-4-yl)methyl)-16-((1H-indol-3-yl)methyl)-13-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-28-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7,22-dibenzyl-19-(3-guanidinopropyl)-10-methyl-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide | CHEMBL1688107
TypeSmall organic molecule
Emp. Form.C72H87N19O14S2
Mol. Mass.1506.71
SMILESC[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r,wU:27.29,13.13,1.0,68.72,49.52,wD:38.40,5.5,64.84,59.100,82.87,97.104,(5.98,2.25,;4.65,1.48,;3.32,2.25,;3.32,3.79,;4.65,4.56,;1.99,4.56,;.65,3.79,;.65,2.25,;1.99,1.48,;-.69,1.48,;1.99,6.1,;.65,6.86,;-.69,6.1,;.65,8.41,;1.99,9.18,;3.32,8.41,;3.48,6.87,;4.98,6.56,;5.75,7.89,;7.26,8.21,;7.73,9.67,;6.71,10.82,;5.2,10.49,;4.72,9.03,;-.69,9.18,;-2.02,8.41,;-2.02,6.86,;-3.35,9.18,;-3.35,10.71,;-4.68,11.49,;-6.01,10.71,;-7.34,11.49,;-7.34,13.03,;-6.01,13.79,;-8.68,13.79,;-4.68,8.41,;-4.68,6.86,;-3.35,6.1,;-6.01,6.1,;-7.34,6.86,;-8.68,6.1,;-10.02,6.86,;-11.35,6.1,;-11.35,4.56,;-10.02,3.79,;-8.68,4.56,;-6.01,4.56,;-4.68,3.79,;-3.35,4.56,;-4.68,2.25,;-6.02,1.49,;-7.35,2.27,;-8.77,1.66,;-9.79,2.81,;-9,4.14,;-7.5,3.8,;-3.35,1.47,;-3.36,-.07,;-2.03,-.85,;-4.7,-.84,;-4.71,-2.38,;-3.38,-3.16,;-.71,-3.02,;.64,-2.26,;1.97,-3.03,;3.32,-2.31,;4.63,-3.11,;4.6,-4.65,;5.98,-2.37,;7.3,-3.16,;8.64,-2.42,;9.97,-3.22,;11.31,-2.47,;11.35,-.94,;10.03,-.14,;8.68,-.88,;5.98,-.83,;4.65,-.06,;3.32,-.83,;1.96,-4.55,;.61,-5.3,;3.27,-5.35,;3.24,-6.89,;1.89,-7.63,;1.86,-9.17,;.51,-9.91,;.47,-11.45,;1.79,-12.25,;1.76,-13.79,;3.15,-11.5,;3.17,-9.96,;4.56,-7.69,;5.91,-6.95,;4.53,-9.23,;-6.03,-.06,;-7.37,-.83,;-8.7,-.04,;-7.38,-2.37,;-8.72,-3.13,;-6.05,-3.14,;-6.05,-4.69,;-7.39,-5.45,;-7.4,-6.99,;-6.07,-7.77,;-6.08,-9.31,;-4.73,-7,;-4.72,-5.46,)|
Structure
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