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TargetMelanocortin receptor 4
LigandBDBM50339347
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736469
EC50 780±n/a nM
Citation Singh AWilczynski AHolder JRWitek RMDirain MLXiang ZEdison ASHaskell-Luevano C Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR. J Med Chem 54:1379-90 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R
Type:PROTEIN
Mol. Mass.:36964.43
Organism:Mus musculus
Description:ChEMBL_1498850
Residue:332
Sequence:
MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50339347
n/a
NameBDBM50339347
Synonyms:(S)-cis-(2S,5S,8S,11S,14R,19R,22S,25R,28S,31S)-22-((1H-imidazol-5-yl)methyl)-2-((1H-indol-3-yl)methyl)-5-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-19-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11,25-dibenzyl-31-(3-guanidinopropyl)-8-methyl-3,6,9,12,20,23,26,29,33-nonaoxo-16,17,35-trithia-1,4,7,10,13,21,24,27,30-nonaazabicyclo[26.4.4]hexatriacontane-14-carboxamide | CHEMBL1688111
TypeSmall organic molecule
Emp. Form.C77H94N20O15S3
Mol. Mass.1635.89
SMILESC[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r,wU:1.0,37.38,46.49,67.109,72.93,wD:13.13,5.5,76.81,57.61,26.28,90.96,105.113,(15.52,-30.42,;16.84,-29.65,;18.15,-30.42,;18.16,-31.93,;16.84,-32.7,;19.48,-32.7,;20.79,-31.94,;20.79,-30.41,;19.47,-29.65,;22.11,-29.64,;19.49,-34.23,;20.81,-34.97,;22.13,-34.2,;20.82,-36.51,;22.33,-36.74,;22.88,-38.16,;22.06,-39.45,;23.03,-40.63,;24.45,-40.08,;25.81,-40.76,;27.09,-39.93,;26.99,-38.4,;25.64,-37.72,;24.36,-38.55,;19.51,-37.28,;18.15,-36.56,;16.86,-37.39,;16.79,-35.85,;15.42,-35.09,;15.4,-33.53,;14.04,-32.76,;12.69,-33.55,;11.33,-32.79,;12.71,-35.12,;15.51,-36.68,;14.22,-37.5,;12.87,-36.8,;14.3,-39.04,;15.65,-39.74,;16.93,-38.91,;18.27,-39.62,;19.57,-38.81,;20.95,-39.55,;13.01,-39.86,;11.62,-39.15,;11.54,-37.59,;10.29,-39.98,;10.26,-41.55,;11.63,-42.31,;11.65,-43.87,;13.01,-44.64,;14.35,-43.84,;14.33,-42.26,;12.96,-41.51,;8.9,-39.25,;7.6,-40.13,;7.65,-41.7,;6.28,-39.33,;5.04,-40.22,;5.02,-41.75,;3.78,-42.63,;4.23,-44.09,;5.75,-44.1,;6.24,-42.65,;6.3,-37.8,;4.99,-37.01,;3.65,-37.75,;5.02,-35.46,;6.41,-34.73,;6.47,-33.17,;14.32,-29.68,;14.29,-28.11,;12.92,-27.35,;12.89,-25.82,;14.2,-25.03,;14.21,-23.47,;15.5,-25.84,;16.81,-25.04,;16.77,-23.52,;15.43,-22.79,;15.39,-21.27,;16.7,-20.47,;18.04,-21.2,;18.07,-22.72,;15.51,-27.37,;16.83,-28.11,;18.11,-27.29,;11.58,-28.17,;11.61,-29.73,;10.21,-27.41,;8.86,-28.21,;7.5,-27.46,;7.46,-25.89,;8.81,-25.09,;8.78,-23.52,;7.41,-22.76,;7.38,-21.2,;6.06,-23.58,;6.1,-25.14,;8.89,-29.78,;10.26,-30.53,;7.56,-30.59,;3.69,-34.64,;3.74,-33.07,;5.11,-32.33,;2.41,-32.25,;2.45,-30.69,;1.02,-33,;-.31,-32.17,;-.25,-30.61,;-1.58,-29.79,;-2.96,-30.52,;-4.3,-29.71,;-3,-32.1,;-1.67,-32.92,)|
Structure
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