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TargetMelanocortin receptor 4
LigandBDBM50339345
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736469
EC50 3210±n/a nM
Citation Singh AWilczynski AHolder JRWitek RMDirain MLXiang ZEdison ASHaskell-Luevano C Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR. J Med Chem 54:1379-90 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R
Type:PROTEIN
Mol. Mass.:36964.43
Organism:Mus musculus
Description:ChEMBL_1498850
Residue:332
Sequence:
MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY
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  Blast E-value cutoff:
BDBM50339345
n/a
NameBDBM50339345
Synonyms:(S)-cis-(2S,5S,8S,11S,14S,17S,22R,25S,28S,31R)-25-((1H-imidazol-5-yl)methyl)-5-((1H-indol-3-yl)methyl)-8-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-22-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-14,31-dibenzyl-2-(3-guanidinopropyl)-11-methyl-3,6,9,12,15,23,26,29,33-nonaoxo-19,20,35-trithia-1,4,7,10,13,16,24,27,30-nonaazabicyclo[26.4.4]hexatriacontane-17-carboxamide | CHEMBL1688106
TypeSmall organic molecule
Emp. Form.C77H94N20O15S3
Mol. Mass.1635.89
SMILESC[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r,wU:5.5,72.93,48.50,37.39,67.109,90.96,wD:27.29,13.13,1.0,76.81,57.61,105.113,(15.4,-29.67,;14.08,-30.48,;14.12,-32.01,;15.48,-32.75,;16.79,-31.94,;15.52,-34.28,;14.2,-35.09,;12.85,-34.35,;12.81,-32.82,;11.54,-35.16,;16.87,-35.03,;16.9,-36.56,;15.59,-37.37,;18.25,-37.3,;19.57,-36.49,;19.53,-34.96,;18.26,-34.08,;18.7,-32.61,;20.24,-32.56,;21.24,-31.39,;22.76,-31.67,;23.27,-33.13,;22.27,-34.3,;20.76,-34.02,;18.3,-38.83,;19.65,-39.57,;20.96,-38.77,;19.7,-41.13,;21.04,-41.89,;21.05,-43.43,;22.39,-44.19,;22.4,-45.73,;23.73,-46.49,;25.06,-45.71,;23.74,-48.02,;18.4,-41.95,;17.03,-41.23,;15.73,-42.05,;15.65,-40.51,;14.31,-39.73,;14.34,-38.18,;13.01,-37.4,;11.66,-38.16,;11.65,-39.71,;12.98,-40.49,;14.36,-41.34,;13.06,-42.17,;11.69,-41.46,;13.13,-43.72,;14.5,-44.42,;15.79,-43.6,;17.15,-44.31,;18.46,-43.49,;19.83,-44.22,;11.84,-44.55,;10.46,-43.83,;10.39,-42.29,;9.16,-44.67,;9.23,-46.22,;7.92,-47.05,;7.84,-48.58,;6.35,-48.98,;5.53,-47.68,;6.5,-46.49,;7.78,-43.96,;7.71,-42.41,;9.01,-41.58,;6.32,-41.69,;6.33,-40.15,;5.01,-39.36,;7.43,-32.91,;8.75,-32.11,;8.71,-30.58,;10.04,-29.79,;10.02,-28.24,;8.67,-27.51,;11.34,-27.46,;11.3,-25.92,;12.62,-25.12,;13.97,-25.86,;15.29,-25.07,;15.24,-23.52,;13.9,-22.78,;12.58,-23.58,;12.69,-28.2,;12.72,-29.73,;11.37,-30.47,;7.41,-29.78,;6.06,-30.53,;7.44,-28.24,;6.13,-27.44,;4.78,-28.18,;3.46,-27.38,;3.5,-25.84,;2.19,-25.05,;.84,-25.78,;-.48,-24.99,;.81,-27.33,;2.12,-28.12,;6.16,-25.9,;4.85,-25.1,;7.51,-25.16,;5,-42.48,;3.65,-41.73,;3.63,-40.19,;2.33,-42.52,;.99,-41.77,;2.35,-44.06,;1.03,-44.84,;-.31,-44.09,;-1.63,-44.88,;-1.61,-46.42,;-2.93,-47.2,;-.26,-47.17,;1.06,-46.38,)|
Structure
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