Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM50339364 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_736488 (CHEMBL1694433) |
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IC50 | 730±n/a nM |
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Citation | Hardcastle, IR; Liu, J; Valeur, E; Watson, A; Ahmed, SU; Blackburn, TJ; Bennaceur, K; Clegg, W; Drummond, C; Endicott, JA; Golding, BT; Griffin, RJ; Gruber, J; Haggerty, K; Harrington, RW; Hutton, C; Kemp, S; Lu, X; McDonnell, JM; Newell, DR; Noble, ME; Payne, SL; Revill, CH; Riedinger, C; Xu, Q; Lunec, J Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency. J Med Chem54:1233-43 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM50339364 |
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n/a |
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Name | BDBM50339364 |
Synonyms: | (+/-)-3-(4-Chlorophenyl)-3-(3-hydroxymethylbenzyloxy)-2-(4-nitrobenzyl)-2,3-dihydroisoindol-1-one | CHEMBL1688269 |
Type | Small organic molecule |
Emp. Form. | C29H23ClN2O5 |
Mol. Mass. | 514.956 |
SMILES | OCc1cccc(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)c1 |
Structure |
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