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TargetBeta-carbonic anhydrase 1
LigandBDBM50339604
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736723 (CHEMBL1695104)
Ki 11600±n/a nM
Citation Davis, RAHofmann, AOsman, AHall, RAMühlschlegel, FAVullo, DInnocenti, ASupuran, CTPoulsen, SA Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases. J Med Chem54:1682-92 (2011) [PubMed]  Article
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Beta-carbonic anhydrase 1
Name:Beta-carbonic anhydrase 1
Synonyms:β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1
Type:Enzyme
Mol. Mass.:18186.06
Organism:Mycobacterium tuberculosis
Description:The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays.
Residue:163
Sequence:
MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAG
CVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESY
PDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
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BDBM50339604
n/a
NameBDBM50339604
Synonyms:CHEMBL605189 | N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide
TypeSmall organic molecule
Emp. Form.C12H16ClNO2
Mol. Mass.241.714
SMILESCCCCNC(=O)Cc1ccc(O)c(Cl)c1
Structure
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