| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
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| Ligand | BDBM50339605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_734829 (CHEMBL1692979) |
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| Ki | 10400±n/a nM |
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| Citation |  Granchi, C; Roy, S; Giacomelli, C; Macchia, M; Tuccinardi, T; Martinelli, A; Lanza, M; Betti, L; Giannaccini, G; Lucacchini, A; Funel, N; León, LG; Giovannetti, E; Peters, GJ; Palchaudhuri, R; Calvaresi, EC; Hergenrother, PJ; Minutolo, F Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. J Med Chem54:1599-612 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| L-lactate dehydrogenase A chain |
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| Name: | L-lactate dehydrogenase A chain |
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| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
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| Type: | Protein |
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| Mol. Mass.: | 36694.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00338::PDB Code: 4ajp |
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| Residue: | 332 |
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| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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| BDBM50339605 |
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| n/a |
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| Name | BDBM50339605 |
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| Synonyms: | 1-Hydroxy-5-phenyl-1H-indole-2-carboxylic Acid | CHEMBL1688788 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11NO3 |
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| Mol. Mass. | 253.2527 |
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| SMILES | OC(=O)c1cc2cc(ccc2n1O)-c1ccccc1 |
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| Structure | 
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