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TargetRAF proto-oncogene serine/threonine-protein kinase
LigandBDBM50339610
Substrate/Competitorn/a
Meas. Tech.ChEMBL_734962 (CHEMBL1693569)
IC50 11±n/a nM
Citation Gould, AEAdams, RAdhikari, SAertgeerts, KAfroze, RBlackburn, CCalderwood, EFChau, RChouitar, JDuffey, MOEngland, DBFarrer, CForsyth, NGarcia, KGaulin, JGreenspan, PDGuo, RHarrison, SJHuang, SCIartchouk, NJanowick, DKim, MSKulkarni, BLangston, SPLiu, JXMa, LTMenon, SMizutani, HPaske, ERenou, CCRezaei, MRowland, RSSintchak, MDSmith, MDStroud, SGTregay, MTian, YVeiby, OPVos, TJVyskocil, SWilliams, JXu, TYang, JJYano, JZeng, HZhang, DMZhang, QGalvin, KM Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors. J Med Chem54:1836-46 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase
Name:RAF proto-oncogene serine/threonine-protein kinase
Synonyms:C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:Serine/threonine-protein kinase
Mol. Mass.:73082.52
Organism:Homo sapiens (Human)
Description:P04049
Residue:648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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  Blast E-value cutoff:
BDBM50339610
n/a
NameBDBM50339610
Synonyms:4-{[7-({[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]amino}carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-N-methylpyridine-2-carboxamide | CHEMBL1688866
TypeSmall organic molecule
Emp. Form.C26H25F3N4O3
Mol. Mass.498.4969
SMILESCNC(=O)c1cc(Oc2ccc3CCC(Cc3c2)C(=O)Nc2cc(CN)cc(c2)C(F)(F)F)ccn1
Structure
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