| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50339636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_735070 (CHEMBL1693911) |
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| IC50 | 10000±n/a nM |
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| Citation |  Laborde, E; Macsata, RW; Meng, F; Peterson, BT; Robinson, L; Schow, SR; Simon, RJ; Xu, H; Baba, K; Inagaki, H; Ishiwata, Y; Jomori, T; Matsumoto, Y; Miyachi, A; Nakamura, T; Okamoto, M; Handel, TM; Bernard, CC Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function. J Med Chem54:1667-81 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C CKR-2 | CC-CKR-2 | CCR-2 | CCR2_RAT | CD_antigen=CD192 | Ccr2 | Cmkbr2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42771.06 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_819962 |
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| Residue: | 373 |
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| Sequence: | MEDSNMLPQFIHGILSTSHSLFPRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPP
LYSLVFIFGFVGNMLVIIILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANEWV
FGNIMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVV
AVFASLPGIIFTKSEQEDDQHTCGPYFPTIWKNFQTIMRNILSLILPLLVMVICYSGILH
TLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQEFLGMSNCVVDMHLDQAM
QVTETLGMTHCCVNPIIYAFVGEKFRRYLSIFFRKHIAKNLCKQCPVFYRETADRVSSTF
TPSTGEQEVSVGL
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| BDBM50339636 |
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| n/a |
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| Name | BDBM50339636 |
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| Synonyms: | 1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea Hydrochloride | CHEMBL1688889 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H33N7O3 |
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| Mol. Mass. | 467.5639 |
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| SMILES | CC(C)Oc1cccc(NC(=O)NC(=O)c2cc3c(C)nn(C)c3nc2N(C)CCN(C)C)c1 |
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| Structure | 
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