Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50339723 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_735257 (CHEMBL1694519) |
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Ki | 15±n/a nM |
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Citation | Watson, NS; Adams, C; Belton, D; Brown, D; Burns-Kurtis, CL; Chaudry, L; Chan, C; Convery, MA; Davies, DE; Exall, AM; Harling, JD; Irvine, S; Irving, WR; Kleanthous, S; McLay, IM; Pateman, AJ; Patikis, AN; Roethke, TJ; Senger, S; Stelman, GJ; Toomey, JR; West, RI; Whittaker, C; Zhou, P; Young, RJ The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs. Bioorg Med Chem Lett21:1588-92 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50339723 |
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n/a |
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Name | BDBM50339723 |
Synonyms: | (S)-3-chloro-N-(2-oxo-1-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrrolidin-3-yl)-1H-indole-6-sulfonamide | CHEMBL1689020 |
Type | Small organic molecule |
Emp. Form. | C21H21ClN4O3S |
Mol. Mass. | 444.934 |
SMILES | Clc1c[nH]c2cc(ccc12)S(=O)(=O)N[C@H]1CCN(C1=O)c1ccc2CCNCc2c1 |r| |
Structure |
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