Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProstaglandin D2 receptor 2
LigandBDBM50339751
Substrate/Competitorn/a
Meas. Tech.ChEMBL_735525 (CHEMBL1693030)
IC50 1±n/a nM
Citation Luker, TBonnert, RPaine, SWSchmidt, JSargent, CCook, ARCook, AGardiner, PHill, SWeyman-Jones, CPatel, AThom, SThorne, P Zwitterionic CRTh2 antagonists. J Med Chem54:1779-88 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50339751
n/a
NameBDBM50339751
Synonyms:(S)-2-(4-chloro-2-((4-(2-(4-fluorophenyl)acetyl)-3-methylpiperazin-1-yl)methyl)phenoxy)acetic acid | CHEMBL1689127
TypeSmall organic molecule
Emp. Form.C22H24ClFN2O4
Mol. Mass.434.888
SMILESC[C@H]1CN(Cc2cc(Cl)ccc2OCC(O)=O)CCN1C(=O)Cc1ccc(F)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: