Reaction Details |
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Target | Carbonic anhydrase 9 |
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Ligand | BDBM54376 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_735541 (CHEMBL1693046) |
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Ki | 58±n/a nM |
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Citation | Pacchiano, F; Carta, F; McDonald, PC; Lou, Y; Vullo, D; Scozzafava, A; Dedhar, S; Supuran, CT Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem54:1896-902 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 9 |
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Name: | Carbonic anhydrase 9 |
Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
Type: | Enzyme |
Mol. Mass.: | 49669.03 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 459 |
Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
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BDBM54376 |
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n/a |
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Name | BDBM54376 |
Synonyms: | 6-Hexyl-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester | 6-hexyl-7-hydroxy-2-keto-chromene-3-carboxylic acid ethyl ester | 6-hexyl-7-hydroxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | MLS000777587 | SMR000413981 | cid_5545047 | ethyl 6-hexyl-7-hydroxy-2-oxochromene-3-carboxylate | ethyl 6-hexyl-7-oxidanyl-2-oxidanylidene-chromene-3-carboxylate |
Type | Small organic molecule |
Emp. Form. | C18H22O5 |
Mol. Mass. | 318.3643 |
SMILES | CCCCCCc1cc2cc(C(=O)OCC)c(=O)oc2cc1O |
Structure |
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