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TargetCarbonic anhydrase 12
LigandBDBM50334356
Substrate/Competitorn/a
Meas. Tech.ChEMBL_735542 (CHEMBL1693047)
Ki 4.3±n/a nM
Citation Pacchiano, FCarta, FMcDonald, PCLou, YVullo, DScozzafava, ADedhar, SSupuran, CT Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem54:1896-902 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase 12
Synonyms:CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50334356
n/a
NameBDBM50334356
Synonyms:4-(3-(4-iodophenyl)ureido)benzenesulfonamide | 4-{[(4'-Iodophenyl)carbamoyl]amino}benzenesulfonamide | CHEMBL1643292
TypeSmall organic molecule
Emp. Form.C13H12IN3O3S
Mol. Mass.417.222
SMILESNS(=O)(=O)c1ccc(NC(=O)Nc2ccc(I)cc2)cc1
Structure
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