| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
|---|
| Ligand | BDBM50334347 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_735539 (CHEMBL1693044) |
|---|
| Ki | 604±n/a nM |
|---|
| Citation |  Pacchiano, F; Carta, F; McDonald, PC; Lou, Y; Vullo, D; Scozzafava, A; Dedhar, S; Supuran, CT Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem54:1896-902 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 1 |
|---|
| Name: | Carbonic anhydrase 1 |
|---|
| Synonyms: | CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28873.37 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00915 |
|---|
| Residue: | 261 |
|---|
| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
|
|
|
|---|
| BDBM50334347 |
|---|
| n/a |
|---|
| Name | BDBM50334347 |
|---|
| Synonyms: | 4-(3-(4-phenoxyphenyl)ureido)benzenesulfonamide | 4-({[(4'-Phenoxyphenyl)amino]carbonyl}amino)benzenesulfonamide | CHEMBL1643302 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17N3O4S |
|---|
| Mol. Mass. | 383.421 |
|---|
| SMILES | NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
