| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 2 |
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| Ligand | BDBM21447 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_735551 (CHEMBL1693159) |
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| IC50 | 40±n/a nM |
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| Citation |  Sleebs, BE; Czabotar, PE; Fairbrother, WJ; Fairlie, WD; Flygare, JA; Huang, DC; Kersten, WJ; Koehler, MF; Lessene, G; Lowes, K; Parisot, JP; Smith, BJ; Smith, ML; Souers, AJ; Street, IP; Yang, H; Baell, JB Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. J Med Chem54:1914-26 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 2 |
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| Name: | Bcl-2-like protein 2 |
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| Synonyms: | Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271 |
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| Type: | Protein |
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| Mol. Mass.: | 20742.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 193 |
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| Sequence: | MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG
QVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL
GALVTVGAFFASK
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| BDBM21447 |
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| n/a |
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| Name | BDBM21447 |
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| Synonyms: | 4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide | ABT-737 | CHEMBL376408 | N-Benylpiperazine derivative, 2 | US11760752, Compound ABT-737 | US9125913, ABT-737 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H45ClN6O5S2 |
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| Mol. Mass. | 813.427 |
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| SMILES | CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r| |
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| Structure | 
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