Reaction Details |
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Target | Squalene synthase |
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Ligand | BDBM50339916 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_740875 (CHEMBL1763976) |
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IC50 | 370±n/a nM |
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Citation | Griebenow, N; Flessner, T; Buchmueller, A; Raabe, M; Bischoff, H; Kolkhof, P Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors. Bioorg Med Chem Lett21:2554-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Squalene synthase |
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Name: | Squalene synthase |
Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
Type: | PROTEIN |
Mol. Mass.: | 48114.76 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1352847 |
Residue: | 417 |
Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
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BDBM50339916 |
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n/a |
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Name | BDBM50339916 |
Synonyms: | CHEMBL1761660 | trans-rac-7-chloro-1-isobutyl-5-(2-methoxyphenyl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one |
Type | Small organic molecule |
Emp. Form. | C28H35ClN2O3 |
Mol. Mass. | 483.042 |
SMILES | COc1ccccc1[C@H]1CN(CC(=O)N2CCCCC2)C(=O)[C@H](CC(C)C)c2ccc(Cl)cc12 |r| |
Structure |
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