| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50339919 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_740875 (CHEMBL1763976) |
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| IC50 | 500±n/a nM |
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| Citation |  Griebenow, N; Flessner, T; Buchmueller, A; Raabe, M; Bischoff, H; Kolkhof, P Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors. Bioorg Med Chem Lett21:2554-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48114.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1352847 |
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| Residue: | 417 |
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| Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
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| BDBM50339919 |
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| n/a |
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| Name | BDBM50339919 |
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| Synonyms: | CHEMBL1761661 | trans-rac-1-(2-(7-chloro-1-isobutyl-5-(2-methoxyphenyl)-2-oxo-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetyl)piperidine-4-carboxylic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35ClN2O5 |
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| Mol. Mass. | 527.052 |
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| SMILES | COc1ccccc1[C@H]1CN(CC(=O)N2CCC(CC2)C(O)=O)C(=O)[C@H](CC(C)C)c2ccc(Cl)cc12 |r| |
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| Structure | 
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