| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM50340043 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_739869 (CHEMBL1762929) |
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| Ki | 6.7±n/a nM |
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| Citation |  Harris, JM; Neustadt, BR; Zhang, H; Lachowicz, J; Cohen-Williams, M; Varty, G; Hao, J; Stamford, AW Potent and selective adenosine A(2A) receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones. Bioorg Med Chem Lett21:2497-501 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM50340043 |
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| n/a |
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| Name | BDBM50340043 |
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| Synonyms: | 5-amino-2-(3-chlorobenzyl)-7-(2-(4-morpholinopiperidin-1-yl)ethyl)-2H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-3(7H)-one | CHEMBL1762627 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30ClN9O2 |
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| Mol. Mass. | 512.007 |
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| SMILES | Nc1nc2n(CCN3CCC(CC3)N3CCOCC3)ncc2c2nn(Cc3cccc(Cl)c3)c(=O)n12 |
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| Structure | 
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