| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Ligand | BDBM50340378 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_740938 (CHEMBL1764082) |
|---|
| IC50 | >4000±n/a nM |
|---|
| Citation |  Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome. Bioorg Med Chem Lett21:2568-72 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 11-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase type 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_MOUSE | Hsd11b2 | Hsd11k | NAD-dependent 11-beta-hydroxysteroid dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42201.46 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Purified recombinant mouse 11beta-HSD2. |
|---|
| Residue: | 386 |
|---|
| Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVV
LAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPG
ALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELS
PVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIA
LLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYI
EHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRR
CFLQNFFINHLLPRALRPGQHGPAPA
|
|
|
|---|
| BDBM50340378 |
|---|
| n/a |
|---|
| Name | BDBM50340378 |
|---|
| Synonyms: | 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole | CHEMBL1761313 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H28F3N3O2S |
|---|
| Mol. Mass. | 455.537 |
|---|
| SMILES | CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C |
|---|
| Structure | 
|
|---|
Search and Browse
