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TargetTranscription factor Jun
LigandBDBM50340626
Substrate/Competitorn/a
Meas. Tech.ChEMBL_739507 (CHEMBL1763333)
IC50 130±n/a nM
Citation He, YKamenecka, TMShin, YSong, XJiang, RNoel, RDuckett, DChen, WLing, YYCameron, MDLin, LKhan, SKoenig, MLoGrasso, PV Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett21:1719-23 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcription factor Jun
Name:Transcription factor Jun
Synonyms:AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:n/a
Mol. Mass.:35683.24
Organism:Homo sapiens (Human)
Description:P05412
Residue:331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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  Blast E-value cutoff:
BDBM50340626
n/a
NameBDBM50340626
Synonyms:8-cyclopropyl-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | CHEMBL1761581
TypeSmall organic molecule
Emp. Form.C27H27N9O
Mol. Mass.493.563
SMILESCn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1C1CC1
Structure
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