Reaction Details |
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Target | Nociceptin receptor |
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Ligand | BDBM50340682 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_740151 (CHEMBL1763211) |
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IC50 | 152.9±n/a nM |
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Citation | Del Giudice, MR; Borioni, A; Bastanzio, G; Sbraccia, M; Mustazza, C; Sestili, I Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor. Eur J Med Chem46:1207-21 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nociceptin receptor |
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Name: | Nociceptin receptor |
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40702.87 |
Organism: | Homo sapiens (Human) |
Description: | P41146 |
Residue: | 370 |
Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM50340682 |
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n/a |
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Name | BDBM50340682 |
Synonyms: | CHEMBL1762411 | N-(4-amino-2-methylquinolin-6-yl)-2-[4-(10-aminodecylaminomethyl)phenoxymethyl]benzamide |
Type | Small organic molecule |
Emp. Form. | C35H45N5O2 |
Mol. Mass. | 567.7641 |
SMILES | Cc1cc(N)c2cc(NC(=O)c3ccccc3COc3ccc(CNCCCCCCCCCCN)cc3)ccc2n1 |
Structure |
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