| Reaction Details |
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 | Report a problem with these data |
| Target | Mas-related G-protein coupled receptor member X1 |
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| Ligand | BDBM50340746 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_740644 (CHEMBL1763646) |
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| IC50 | 40±n/a nM |
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| Citation |  Bayrakdarian, M; Butterworth, J; Hu, YJ; Santhakumar, V; Tomaszewski, MJ Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists. Bioorg Med Chem Lett21:2102-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mas-related G-protein coupled receptor member X1 |
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| Name: | Mas-related G-protein coupled receptor member X1 |
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| Synonyms: | MRGPRX1 | MRGX1 | MRGX1_HUMAN | SNSR3 | SNSR4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36253.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_516621 |
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| Residue: | 322 |
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| Sequence: | MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNA
FSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTER
CLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFIT
VAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFL
WIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASE
VDEGGGQLPEEILELSGSRLEQ
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| BDBM50340746 |
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| n/a |
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| Name | BDBM50340746 |
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| Synonyms: | 2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)piperazin-1-yl)-N-(pyridin-4-ylmethyl)-N-((tetrahydrofuran-2-yl)methyl)acetamide | CHEMBL1762701 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36ClN7O2 |
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| Mol. Mass. | 550.095 |
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| SMILES | Clc1ccc(CCNc2nccc(n2)N2CCN(CC(=O)N(CC3CCCO3)Cc3ccncc3)CC2)cc1 |
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| Structure | 
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