Reaction Details |
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Target | Lethal factor |
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Ligand | BDBM50340771 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_740261 (CHEMBL1764161) |
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Ki | 1.4±n/a nM |
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Citation | Kim, S; Jiao, GS; Moayeri, M; Crown, D; Cregar-Hernandez, L; McKasson, L; Margosiak, SA; Leppla, SH; Johnson, AT Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy. Bioorg Med Chem Lett21:2030-3 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lethal factor |
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Name: | Lethal factor |
Synonyms: | Anthrax Lethal Factor (LF) | Anthrax lethal factor | Antrax lethal toxin | LEF_BACAN | lef | lethal factor |
Type: | PROTEIN |
Mol. Mass.: | 93758.56 |
Organism: | Bacillus anthracis |
Description: | ChEMBL_1460338 |
Residue: | 809 |
Sequence: | MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEE
RNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGD
ITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNV
YYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLE
QNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLAR
YEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSS
DFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYD
INQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLT
ATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSP
DTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNIN
QEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNG
RFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHE
FGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHST
DHAERLKVQKNAPKTFQFINDQIKFIINS
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BDBM50340771 |
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n/a |
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Name | BDBM50340771 |
Synonyms: | (S)-6-(4-chlorobenzylamino)-2-((R)-2-(4-fluoro-3-methylphenyl)-2-methoxyethyl)-N-hydroxyhexanamide | CHEMBL1760330 |
Type | Small organic molecule |
Emp. Form. | C23H30ClFN2O3 |
Mol. Mass. | 436.947 |
SMILES | CO[C@H](C[C@H](CCCCNCc1ccc(Cl)cc1)C(=O)NO)c1ccc(F)c(C)c1 |r| |
Structure |
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